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Further into the cascade, H2O2, a common reactive oxygen species, activates the small GTPase Ral

Funding This study was supported by the Agencia Nacional de Promocin de la Investigacin, el Desarrollo Tecnolgico y la Innovacin (ANPCyT) (IP-COVID-19-234), Consejo Nacional de Investigaciones Cientficas y Tcnicas (CONICET), Universidad de Buenos Aires (UBA) and Universidad Nacional de San Martn (UNSAM)

These results demonstrate that SPAE effectively reduces DEX-induced DNA damage in hepatic tissues, with the 800 mg/kg dose offering greater genoprotective effects than 400 mg/kg (Table 4

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Collectively, these enzymatic systems function synergistically to counteract oxidative stress 41